Location Hamburg

Discovery Research ScreeningPort

The Fraunhofer ITMP in Hamburg has extensive expertise in small molecules, which continue to be the dominant drug class. In our laboratories in Hamburg, we have high-throughput screening systems, various compound libraries and a broad portfolio of established assay formats. Our unique selling proposition is our ability to synergistically complement the laboratory research work with the expertise of our data scientists. We also have a powerful medical data science infrastructure with the Fraunhofer Edge Cloud and a toolbox of algorithms and datasets.

To drive our projects forward, we have introduced an agile project management based on agile project teams. There are four agile teams in total: Stem Cell Biology, High-Throughput Screening, Infection Biology and Medical Data Science. These teams enable us to respond to new challenges with high flexibility and develop innovative interdisciplinary solutions for our clients.

Our goal is to formulate and validate hypotheses for curing diseases. Based on these hypotheses, we search for diagnostic and therapeutic answers with chemical entities and transfer them to preclinical development. We test our results in innovative, complex in vitro test systems based on pluripotent stem cells or organoids derived from them, such as a blood-brain barrier model. 

Together with the University Medical Center Hamburg-Eppendorf (UKE), we operate translational laboratories in the fields of renal research and neuroimmunology. In addition, we have established a structural virology unit with the Bernhard Nocht Institute for Tropical Medicine and the BMBF Rosenthal junior research group, and a partnership with DESY for protein structure elucidation.

As an EU-OPENSCREEN site and through our involvement in EU research projects, we are also an important part of an established network of academic and clinical partners in the European research landscape.

Teams at the location

 

High-Throughput Screening

The High-Throughput Screening Team offers comprehensive pre-clinical drug discovery services. This includes in-vitro methods relating to assay development, high-throughput screening, hit validation and ADMET profiling. This is complemented with in silico methods for protein structure prediction followed by virtual screening. An end-to-end bioinformatics and chemoinformatics platform allows for informed prioritization of the identified chemical compounds.

 

Stem Cell Biology

 

To understand diseases and test therapies, model systems are needed that reproduce disease-related phenotypes in a cell culture dish. Human induced pluripotent stem cells (hiPSCs) are a valuable source of these models because they can be derived from patient cells and differentiated into the affected tissues. These can then be used to test drug candidates for efficacy and toxicity.

 

Infection Biology

 

The team infection biology aims to develop novel therapeutic approaches for the treatment of bacterial, viral and parasitic infections.

By combining a broad spectrum of experimental and computational methods we drive the development of innovative and safe drugs in collaboration with our customers.

 

Medical Data Science

 

The Medical Data Science team develops innovative, AI-driven solutions for health research and concentrates on four areas: Drugs, Devices, Data, Diagnostics (4D). With a focus on immune-mediated, neurodegenerative, and infectious diseases, we combine machine learning and biostatistical analyses in close collaboration with clinics, pharmaceutical companies, and academic partners.

Agile Project Teams

 

At Fraunhofer ITMP Discovery Research ScreeningPort, we work in four agile project teams that enable us to respond to new challenges with high flexibility and develop innovative interdisciplinary solutions for our clients.