Fraunhofer Institute for Translational Medicine and Pharmacology ITMP NONEGON (Novel Inhibitors targeting DXR in Neisseria Gonorrhoeae)
Gonorrhea is a sexually transmitted disease caused by the Gram-negative bacterium Neisseria gonorrhoeae. Within NONEGON Fraunhofer ITMP collaborates with partners from Turkey and Thailand on the development of novel inhibitors of the enzyme DXR (DXP reductoisomerase), that catalyzes the second step in the methylerithritol phosphate (MEP) pathway that is an essential biosynthetic pathway in bacteria. In the project Fraunhofer ITMP is responsible for a high-throughput screening campaign for novel enzyme inhibitors and characterization of the hits by affinity measurements.
