Publications Translational Medicine

A - C

Agueusop, I., Musholt, P.B., Klaus, B., Hightower, K., Kannt, A.
Short-term variability of the human serum metabolome depending on nutritional and metabolic health status (2020) Scientific reports, 10 (1), 16310. https://doi.org/10.1038/s41598-020-72914-7

Aguilar, R.C., Salmanton-García, J., Carney, J., Böll, B., Kochanek, M., Jazmati, N., Cornely, O.A., Vehreschild, M.J.G.T.
Clostridioides difficile infections in the intensive care unit: a monocentric cohort study (2020) Infection, 48 (3), 421–427. https://doi.org/10.1007/s15010-020-01413-8

Allanore, Y., Bozzi, S., Terlinden, A., Huscher, D., Amand, C., Soubrane, C., Siegert, E., Czirják, L., Carreira, P.E., Hachulla, E., Zanatta, E., Li, M., Airò, P., Mendoza, F.A., Rosato, E., Distler, O.
Health Assessment Questionnaire-Disability Index (HAQ-DI) use in modelling disease progression in diffuse cutaneous systemic sclerosis: an analysis from the EUSTAR database (2020) Arthritis research & therapy, 22 (1), 257. https://doi.org/10.1186/s13075-020-02329-2

Anastasiou, O.E., Thodou, V., Berger, A., Wedemeyer, H., Ciesek, S.
Comprehensive Evaluation of Hepatitis E Serology and Molecular Testing in a Large Cohort (2020) Pathogens (Basel, Switzerland), 9 (2). https://doi.org/10.3390/pathogens9020137

Anders, M., Anders, B., Kreuzer, M., Zinn, S., Walter, C.
Application of Referencing Techniques in EEG-Based Recordings of Contact Heat Evoked Potentials (CHEPS) (2020) Frontiers in human neuroscience, 14, 559969. https://doi.org/10.3389/fnhum.2020.559969

Appelt-Menzel, A., Oerter, S., Mathew, S., Haferkamp, U., Hartmann, C., Jung, M., Neuhaus, W., Pless, O.
Human iPSC-Derived Blood-Brain Barrier Models: Valuable Tools for Preclinical Drug Discovery and Development? (2020) Current protocols in stem cell biology, 55 (1), e122. https://doi.org/10.1002/cpsc.122

Assmann, G., Köhm, M., Schuster, V., Behrens, F., Mössner, R., Magnolo, N., Oji, V., Burkhardt, H., Hüffmeier, U.
Genetic variants in FBLIM1 gene do not contribute to SAPHO syndrome and chronic recurrent multifocal osteomyelitis in typical patient groups (2020) BMC medical genetics, 21 (1), 102. https://doi.org/10.1186/s12881-020-01037-7

Bacher, P., Rosati, E., Esser, D., Martini, G.R., Saggau, C., Schiminsky, E., Dargvainiene, J., Schröder, I., Wieters, I., Khodamoradi, Y., Eberhardt, F., Vehreschild, Maria J G T, Neb, H., Sonntagbauer, M., Conrad, C., Tran, F., Rosenstiel, P., Markewitz, R., Wandinger, K.-P., Augustin, M., Rybniker, J., Kochanek, M., Leypoldt, F., Cornely, O.A., Koehler, P., Franke, A., Scheffold, A.
Low-Avidity CD4(+) T Cell Responses to SARS-CoV-2 in Unexposed Individuals and Humans with Severe COVID-19 (2020) Immunity, 53 (6), 1258-1271.e5. https://doi.org/10.1016/j.immuni.2020.11.016

Ballo, O., Kreisel, E.-M., Eladly, F., Brunnberg, U., Stratmann, J., Hunyady, P., Hogardt, M., Wichelhaus, T.A., Kempf, V.A.J., Steffen, B., Vehreschild, J.J., Vehreschild, M.J.G.T., Finkelmeier, F., Serve, H., Brandts, C.H.
Use of carbapenems and glycopeptides increases risk for Clostridioides difficile infections in acute myeloid leukemia patients undergoing intensive induction chemotherapy (2020) Annals of hematology, 99 (11), 2547–2553. https://doi.org/10.1007/s00277-020-04274-1

Baraliakos, X., Sewerin, P., Miguel, E. de, Pournara, E., Kleinmond, C., Wiedon, A., Behrens, F.
Achilles tendon enthesitis evaluated by MRI assessments in patients with axial spondyloarthritis and psoriatic arthritis: a report of the methodology of the ACHILLES trial (2020) BMC musculoskeletal disorders, 21 (1), 767. https://doi.org/10.1186/s12891-020-03775-4

Basavarajappa, D., Uebbing, S., Kreiss, M., Lukic, A., Suess, B., Steinhilber, D., Samuelsson, B., Rådmark, O.
Dicer up-regulation by inhibition of specific proteolysis in differentiating monocytic cells (2020) Proceedings of the National Academy of Sciences of the United States of America, 117 (15), 8573–8583. https://doi.org/10.1073/pnas.1916249117

Behrens, F., Rech, J., Thaçi, D., Zinke, S., Rothnie, K.J., Oefner Daamen, C., Leipe, J.
High rates of therapeutic changes in patients with psoriatic arthritis receiving treatment with disease-modifying antirheumatic drugs: a cross-sectional study (2020) Modern rheumatology, 1–23. https://doi.org/10.1080/14397595.2020.1816597

Behrens, F., Tony, H.-P., Koehm, M., Schwaneck, E.C., Gnann, H., Greger, G., Burkhardt, H., Schmalzing, M.
Correction to: Sustained improvement in work outcomes in employed patients with rheumatoid arthritis during 2 years of adalimumab therapy: an observational cohort study (2020) Clinical rheumatology, 39 (8), 2491. https://doi.org/10.1007/s10067-020-05168-3

Behrens, F., Tony, H.-P., Koehm, M., Schwaneck, E.C., Gnann, H., Greger, G., Burkhardt, H., Schmalzing, M.
Sustained improvement in work outcomes in employed patients with rheumatoid arthritis during 2 years of adalimumab therapy: an observational cohort study (2020) Clinical rheumatology, 39 (9), 2583–2592. https://doi.org/10.1007/s10067-020-05038-y

Biehl, L.M., Vehreschild, Maria J G T
Contact precautions: no benefits, no indication (2020) The Lancet. Infectious diseases, 20 (5), 516–517. https://doi.org/10.1016/S1473-3099(20)30017-7

Blum, L., Geisslinger, G., Parnham, M.J., Grünweller, A., Schiffmann, S.
Natural antiviral compound silvestrol modulates human monocyte-derived macrophages and dendritic cells (2020) Journal of cellular and molecular medicine, 24 (12), 6988–6999. https://doi.org/10.1111/jcmm.15360

Blum, L., Gul, S., Ulshöfer, T., Henke, M., Krieg, R., Berneburg, I., Thomas, D., Trautmann, S., Kurz, J., Geyer, J., Geisslinger, G., Becker, K., Parnham, M.J., Schiffmann, S.
In-vitro safety and off-target profile of the anti-parasitic arylmethylaminosteroid 1o (2020) Scientific reports, 10 (1), 7534. https://doi.org/10.1038/s41598-020-64382-w

Bojkova, D., Bechtel, M., McLaughlin, K.-M., McGreig, J.E., Klann, K., Bellinghausen, C., Rohde, G., Jonigk, D., Braubach, P., Ciesek, S., Münch, C., Wass, M.N., Michaelis, M., Cinatl, J., JR
Aprotinin Inhibits SARS-CoV-2 Replication (2020) Cells, 9 (11). https://doi.org/10.3390/cells9112377

Bojkova, D., Klann, K., Koch, B., Widera, M., Krause, D., Ciesek, S., Cinatl, J., Münch, C.
Proteomics of SARS-CoV-2-infected host cells reveals therapy targets (2020) Nature, 583 (7816), 469–472. https://doi.org/10.1038/s41586-020-2332-7

Bojkova, D., Wagner, J.U.G., Shumliakivska, M., Aslan, G.S., Saleem, U., Hansen, A., Luxán, G., Günther, S., Pham, M.D., Krishnan, J., Harter, P.N., Ermel, U.H., Frangakis, A.S., Milting, H., Zeiher, A.M., Klingel, K., Cinatl, J., Dendorfer, A., Eschenhagen, T., Tschöpe, C., Ciesek, S., Dimmeler, S.
SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes (2020) Cardiovascular research, 116 (14), 2207–2215. https://doi.org/10.1093/cvr/cvaa267

Bojkova, D., Westhaus, S., Costa, R., Timmer, L., Funkenberg, N., Korencak, M., Streeck, H., Vondran, F., Broering, R., Heinrichs, S., Lang, K.S., Ciesek, S.
Sofosbuvir Activates EGFR-Dependent Pathways in Hepatoma Cells with Implications for Liver-Related Pathological Processes (2020) Cells, 9 (4). https://doi.org/10.3390/cells9041003

Brandt, S.C., Ellinger, B., van Nguyen, T., Harder, S., Schlüter, H., Hahnke, R.L., Rühl, M., Schäfer, W., Gand, M.
Aspergillus sydowii: Genome Analysis and Characterization of Two Heterologous Expressed, Non-redundant Xylanases (2020) Frontiers in microbiology, 11, 2154. https://doi.org/10.3389/fmicb.2020.573482

Brunst, S., Kramer, J.S., Kilu, W., Heering, J., Pollinger, J., Hiesinger, K., George, S., Steinhilber, D., Merk, D., Proschak, E.
Systematic Assessment of Fragment Identification for Multitarget Drug Design (2020) ChemMedChem . https://doi.org/10.1002/cmdc.202000858

Bütikofer, L., Varisco, P.A., Distler, O., Kowal-Bielecka, O., Allanore, Y., Riemekasten, G., Villiger, P.M., Adler, S.
ACE inhibitors in SSc patients display a risk factor for scleroderma renal crisis-a EUSTAR analysis (2020) Arthritis research & therapy, 22 (1), 59. https://doi.org/10.1186/s13075-020-2141-2

Chachulski, L., Windshügel, B.
LEADS-FRAG: A Benchmark Data Set for Assessment of Fragment Docking Performance (2020) Journal of chemical information and modeling, 60 (12), 6544–6554. https://doi.org/10.1021/acs.jcim.0c00693

Chaikuad, A., Pollinger, J., Rühl, M., Ni, X., Kilu, W., Heering, J., Merk, D.
Comprehensive Set of Tertiary Complex Structures and Palmitic Acid Binding Provide Molecular Insights into Ligand Design for RXR Isoforms (2020) International journal of molecular sciences, 21 (22). https://doi.org/10.3390/ijms21228457

Charoo, N.A., Abdallah, D.B., Parveen, T., Abrahamsson, B., Cristofoletti, R., Groot, D.W., Langguth, P., Parr, A., Polli, J.E., Mehta, M., Shah, V.P., Tajiri, T., Dressman, J.
Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Moxifloxacin Hydrochloride (2020) Journal of pharmaceutical sciences, 109 (9), 2654–2675. https://doi.org/10.1016/j.xphs.2020.06.007

Cinque, L., Leonibus, C. de, Iavazzo, M., Krahmer, N., Intartaglia, D., Salierno, F.G., Cegli, R. de, Di Malta, C., Svelto, M., Lanzara, C., Maddaluno, M., Wanderlingh, L.G., Huebner, A.K., Cesana, M., Bonn, F., Polishchuk, E., Hübner, C.A., Conte, I., Dikic, I., Mann, M., Ballabio, A., Sacco, F., Grumati, P., Settembre, C.
MiT/TFE factors control ER-phagy via transcriptional regulation of FAM134B (2020) The EMBO journal, 39 (17), e105696. https://doi.org/10.15252/embj.2020105696

Cohnen, J., Kornstädt, L., Hahnefeld, L., Ferreiros, N., Pierre, S., Koehl, U., Deller, T., Geisslinger, G., Scholich, K.
Tumors Provoke Inflammation and Perineural Microlesions at Adjacent Peripheral Nerves (2020) Cells, 9 (2). https://doi.org/10.3390/cells9020320

Corman, V.M., Rabenau, H.F., Adams, O., Oberle, D., Funk, M.B., Keller-Stanislawski, B., Timm, J., Drosten, C., Ciesek, S.
SARS-CoV-2 asymptomatic and symptomatic patients and risk for transfusion transmission (2020) Transfusion, 60 (6), 1119–1122. https://doi.org/10.1111/trf.15841

Cruz-Aguilar, R., Carney, J., Mondaini, V., Vehreschild, M.J.G.T., Griskaitis, M., Salmanton-García, J., Böll, B., Kochanek, M., Seifert, H., Biehl, L.M., Farowski, F.
A quality improvement study on the reduction of central venous catheter-associated bloodstream infections by use of self-disinfecting venous access caps (STERILE) (2020) American journal of infection control . https://doi.org/10.1016/j.ajic.2020.09.002

D - F

Dauth, S., Rakov, H., Sîrbulescu, R.F., Ilieş, I., Weber, J., Batbajar Dugershaw, B., Braun, D., Rehders, M., Wirth, E.K., Führer, D., Schweizer, U., Brix, K.
Function of Cathepsin K in the Central Nervous System of Male Mice is Independent of Its Role in the Thyroid Gland (2020) Cellular and molecular neurobiology, 40 (5), 695–710. https://doi.org/10.1007/s10571-019-00765-6

Davies, K., Lawrence, J., Berry, C., Davis, G., Yu, H., Cai, B., Gonzalez, E., Prantner, I., Kurcz, A., Macovei, I., Pituch, H., Nováková, E., Nyč, O., Gärtner, B., Berger, F.K., Oleastro, M., Cornely, O.A., Vehreschild, M.J.G.T., Pedneault, L., Wilcox, M.
Risk Factors for Primary Clostridium difficile Infection; Results From the Observational Study of Risk Factors for Clostridium difficile Infection in Hospitalized Patients With Infective Diarrhea (ORCHID) (2020) Frontiers in public health, 8, 293. https://doi.org/10.3389/fpubh.2020.00293

de Los Reyes Jiménez, Marta, Lechner, A., Alessandrini, F., Bohnacker, S., Schindela, S., Trompette, A., Haimerl, P., Thomas, D., Henkel, F., Mourão, A., Geerlof, A., Da Costa, C.P., Chaker, A.M., Brüne, B., Nüsing, R., Jakobsson, P.-J., Nockher, W.A., Feige, M.J., Haslbeck, M., Ohnmacht, C., Marsland, B.J., Voehringer, D., Harris, N.L., Schmidt-Weber, C.B., Esser-von Bieren, J.
An anti-inflammatory eicosanoid switch mediates the suppression of type-2 inflammation by helminth larval products (2020) Science translational medicine, 12 (540). https://doi.org/10.1126/scitranslmed.aay0605

Demir, M., Lang, S., Martin, A., Farowski, F., Wisplinghoff, H., Vehreschild, M.J.G.T., Krawczyk, M., Nowag, A., Scholz, C.J., Kretzschmar, A., Roderburg, C., Lammert, F., Goeser, T., Kasper, P., Steffen, H.-M.
Phenotyping non-alcoholic fatty liver disease by the gut microbiota: Ready for prime time? (2020) Journal of gastroenterology and hepatology, 35 (11), 1969–1977. https://doi.org/10.1111/jgh.15071

Duriez, M., Jacquet, A., Hoet, L., Roche, S., Bock, M.-D., Rocher, C., Haussy, G., Vigé, X., Bocskei, Z., Slavnic, T., Martin, V., Guillemot, J.-C., Didier, M., Kannt, A., Orsini, C., Mikol, V., Le Fèvre, A.-C.
A 3D Human Liver Model of Nonalcoholic Steatohepatitis (2020) Journal of clinical and translational hepatology, 8 (4), 359–370. https://doi.org/10.14218/JCTH.2020.00015

Ebert, R., Cumbana, R., Lehmann, C., Kutzner, L., Toewe, A., Ferreirós, N., Parnham, M.J., Schebb, N.H., Steinhilber, D., Kahnt, A.S.
Long-term stimulation of toll-like receptor-2 and -4 upregulates 5-LO and 15-LO-2 expression thereby inducing a lipid mediator shift in human monocyte-derived macrophages (2020) Biochimica et biophysica acta. Molecular and cell biology of lipids, 1865 (9), 158702. https://doi.org/10.1016/j.bbalip.2020.158702

Eis-Hübinger, A.M., Hönemann, M., Wenzel, J.J., Berger, A., Widera, M., Schmidt, B., Aldabbagh, S., Marx, B., Streeck, H., Ciesek, S., Liebert, U.G., Huzly, D., Hengel, H., Panning, M.
Ad hoc laboratory-based surveillance of SARS-CoV-2 by real-time RT-PCR using minipools of RNA prepared from routine respiratory samples (2020) Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 127, 104381. https://doi.org/10.1016/j.jcv.2020.104381

Ellinger, B., Pohlmann, D., Woens, J., Jäkel, F.M., Reinshagen, J., Stocking, C., Prassolov, V.S., Fehse, B., Riecken, K.
A High-Throughput HIV-1 Drug Screening Platform, Based on Lentiviral Vectors and Compatible with Biosafety Level-1 (2020) Viruses, 12 (5). https://doi.org/10.3390/v12050580

Emmerich, A.C., Wellstein, J., Ossipova, E., Baumann, I., Lengqvist, J., Kultima, K., Jakobsson, P.-J., Steinhilber, D., Saul, M.J.
Proteomics-Based Characterization of miR-574-5p Decoy to CUGBP1 Suggests Specificity for mPGES-1 Regulation in Human Lung Cancer Cells (2020) Frontiers in pharmacology, 11, 196. https://doi.org/10.3389/fphar.2020.00196

Fiolka, T., van den Abeele, J., Augustijns, P., Arora, S., Dressman, J.
Biorelevant Two-Stage In Vitro Testing for rDCS Classification and in PBPK Modeling-Case Example Ritonavir (2020) Journal of pharmaceutical sciences, 109 (8), 2512–2526. https://doi.org/10.1016/j.xphs.2020.04.023

Frey, S., Sticht, H., Wilsmann-Theis, D., Gerschütz, A., Wolf, K., Löhr, S., Haskamp, S., Frey, B., Hahn, M., Ekici, A.B., Uebe, S., Thiel, C., Reis, A., Burkhardt, H., Behrens, F., Köhm, M., Rech, J., Schett, G., Assmann, G., Kingo, K., Kõks, S., Mössner, R., Prinz, J.C., Oji, V., Schulz, P., Muñoz, L.E., Kremer, A.E., Wenzel, J., Hüffmeier, U.
Rare Loss-of-Function Mutation in SERPINA3 in Generalized Pustular Psoriasis (2020) The Journal of investigative dermatology, 140 (7), 1451-1455.e13. https://doi.org/10.1016/j.jid.2019.11.024

Fuhrmann, D.C., Mondorf, A., Beifuß, J., Jung, M., Brüne, B.
Hypoxia inhibits ferritinophagy, increases mitochondrial ferritin, and protects from ferroptosis (2020) Redox biology, 36, 101670. https://doi.org/10.1016/j.redox.2020.101670

G - I

Gellrich, L., Heitel, P., Heering, J., Kilu, W., Pollinger, J., Goebel, T., Kahnt, A., Arifi, S., Pogoda, W., Paulke, A., Steinhilber, D., Proschak, E., Wurglics, M., Schubert-Zsilavecz, M., Chaikuad, A., Knapp, S., Bischoff, I., Fürst, R., Merk, D.
l-Thyroxin and the Nonclassical Thyroid Hormone TETRAC Are Potent Activators of PPARγ (2020) Journal of medicinal chemistry, 63 (13), 6727–6740. https://doi.org/10.1021/acs.jmedchem.9b02150

Gerstein, H.C., Paré, G., McQueen, M.J., Lee, S.F., Bangdiwala, S.I., Kannt, A., Hess, S.
Novel Biomarkers for Change in Renal Function in People With Dysglycemia (2020) Diabetes care, 43 (2), 433–439. https://doi.org/10.2337/dc19-1604

Gross, T., Wack, G., Syhr, K.M.J., Tolmachova, T., Seabra, M.C., Geisslinger, G., Niederberger, E., Schmidtko, A., Kallenborn-Gerhardt, W.
Rab27a Contributes to the Processing of Inflammatory Pain in Mice (2020) Cells, 9 (6). https://doi.org/10.3390/cells9061488

Gunne, S., Heinicke, U., Parnham, M.J., Laux, V., Zacharowski, K., Knethen, A. von
Nrf2-A Molecular Target for Sepsis Patients in Critical Care (2020) Biomolecules, 10 (12). https://doi.org/10.3390/biom10121688

Hagenow, J., Hagenow, S., Grau, K., Khanfar, M., Hefke, L., Proschak, E., Stark, H.
Reversible Small Molecule Inhibitors of MAO A and MAO B with Anilide Motifs (2020) Drug design, development and therapy, 14, 371–393. https://doi.org/10.2147/DDDT.S236586

Hahnefeld, L., Gruber, L., Schömel, N., Fischer, C., Mattjus, P., Gurke, R., Beretta, M., Ferreirós, N., Geisslinger, G., Wegner, M.-S.
Ether lipid and sphingolipid expression patterns are estrogen receptor-dependently altered in breast cancer cells (2020) The international journal of biochemistry & cell biology, 127, 105834. https://doi.org/10.1016/j.biocel.2020.105834

Hahnefeld, L., Gurke, R., Thomas, D., Schreiber, Y., Schäfer, S.M.G., Trautmann, S., Snodgrass, I.F., Kratz, D., Geisslinger, G., Ferreirós, N.
Implementation of lipidomics in clinical routine: Can fluoride/citrate blood sampling tubes improve preanalytical stability? (2020) Talanta, 209, 120593. https://doi.org/10.1016/j.talanta.2019.120593

Han, Y., Huard, A., Mora, J., Da Silva, P., Brüne, B., Weigert, A.
IL-36 family cytokines in protective versus destructive inflammation (2020) Cellular signalling, 75, 109773. https://doi.org/10.1016/j.cellsig.2020.109773

Hanke, T., Cheung, S.-Y., Kilu, W., Heering, J., Ni, X., Planz, V., Schierle, S., Faudone, G., Friedrich, M., Wanior, M., Werz, O., Windbergs, M., Proschak, E., Schubert-Zsilavecz, M., Chaikuad, A., Knapp, S., Merk, D.
A Selective Modulator of Peroxisome Proliferator-Activated Receptor γ with an Unprecedented Binding Mode (2020) Journal of medicinal chemistry, 63 (9), 4555–4561. https://doi.org/10.1021/acs.jmedchem.9b01786

Harberts, J., Haferkamp, U., Haugg, S., Fendler, C., Lam, D., Zierold, R., Pless, O., Blick, R.H.
Interfacing human induced pluripotent stem cell-derived neurons with designed nanowire arrays as a future platform for medical applications (2020) Biomaterials science, 8 (9), 2434–2446. https://doi.org/10.1039/d0bm00182a

Hausmann, J., Kubesch, A., Goettlich, C.M., Rey, J., Wächtershäuser, A., Bojunga, J., Blumenstein, I.
Quality of life of patients with head and neck cancer after prophylactic percutaneous-gastrostomy (2020) European journal of clinical nutrition, 74 (4), 565–572. https://doi.org/10.1038/s41430-019-0499-5

Hefke, L., Hiesinger, K., Zhu, W.F., Kramer, J.S., Proschak, E.
Computer-Aided Fragment Growing Strategies to Design Dual Inhibitors of Soluble Epoxide Hydrolase and LTA4 Hydrolase (2020) ACS medicinal chemistry letters, 11 (6), 1244–1249. https://doi.org/10.1021/acsmedchemlett.0c00102

Heinen, S., Schulze, N., Franke, B., Klein, F., Lehmann, C., Vehreschild, M.J.G.T., Gloistein, C., Stecher, M., Vehreschild, J.J.
HEnRY: a DZIF LIMS tool for the collection and documentation of biomaterials in multicentre studies (2020) BMC bioinformatics, 21 (1), 290. https://doi.org/10.1186/s12859-020-03596-1

Heinicke, U., Adam, E., Sonntagbauer, M., Knethen, A. von, Zacharowski, K., Neb, H.
Angiotensin II treatment in COVID-19 patients: more risk than benefit? A single-center experience (2020) Critical care (London, England), 24 (1), 409. https://doi.org/10.1186/s13054-020-03143-7

Hernandez-Olmos, V., Heering, J., Planz, V., Liu, T., Kaps, A., Rajkumar, R., Gramzow, M., Kaiser, A., Schubert-Zsilavecz, M., Parnham, M.J., Windbergs, M., Steinhilber, D., Proschak, E.
First Structure-Activity Relationship Study of Potent BLT2 Agonists as Potential Wound-Healing Promoters (2020) Journal of medicinal chemistry, 63 (20), 11548–11572. https://doi.org/10.1021/acs.jmedchem.0c00588

Hiesinger, K., Kramer, J.S., Beyer, S., Eckes, T., Brunst, S., Flauaus, C., Wittmann, S.K., Weizel, L., Kaiser, A., Kretschmer, S.B.M., George, S., Angioni, C., Heering, J., Geisslinger, G., Schubert-Zsilavecz, M., Schmidtko, A., Pogoryelov, D., Pfeilschifter, J., Hofmann, B., Steinhilber, D., Schwalm, S., Proschak, E.
Design, Synthesis, and Structure-Activity Relationship Studies of Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase (2020) Journal of medicinal chemistry, 63 (20), 11498–11521. https://doi.org/10.1021/acs.jmedchem.0c00561

Hinnah, K., Willems, S., Morstein, J., Heering, J., Hartrampf, F.W.W., Broichhagen, J., Leippe, P., Merk, D., Trauner, D.
Photohormones Enable Optical Control of the Peroxisome Proliferator-Activated Receptor γ (PPARγ) (2020) Journal of medicinal chemistry, 63 (19), 10908–10920. https://doi.org/10.1021/acs.jmedchem.0c00654

Hoehl, S., Berger, A., Ciesek, S., Rabenau, H.F.
Thirty years of CMV seroprevalence-a longitudinal analysis in a German university hospital (2020) European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 39 (6), 1095–1102. https://doi.org/10.1007/s10096-020-03814-x

Hoehl, S., Karaca, O., Kohmer, N., Westhaus, S., Graf, J., Goetsch, U., Ciesek, S.
Assessment of SARS-CoV-2 Transmission on an International Flight and Among a Tourist Group (2020) JAMA network open, 3 (8), e2018044. https://doi.org/10.1001/jamanetworkopen.2020.18044

Hoehl, S., Rabenau, H., Berger, A., Kortenbusch, M., Cinatl, J., Bojkova, D., Behrens, P., Böddinghaus, B., Götsch, U., Naujoks, F., Neumann, P., Schork, J., Tiarks-Jungk, P., Walczok, A., Eickmann, M., Vehreschild, Maria J G T, Kann, G., Wolf, T., Gottschalk, R., Ciesek, S.
Evidence of SARS-CoV-2 Infection in Returning Travelers from Wuhan, China (2020) The New England journal of medicine, 382 (13), 1278–1280. https://doi.org/10.1056/NEJMc2001899

Hofsäss, M.A., Dressman, J.
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Ziegler, N., Bader, E., Epanchintsev, A., Margerie, D., Kannt, A., Schmoll, D.
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Annak, O., Heidegger, T., Walter, C., Deichmann, R., Nöth, U., Hansen-Goos, O., Ziemann, U., Lötsch, J.
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Astakhova, A., Chistyakov, D., Thomas, D., Geisslinger, G., Brüne, B., Sergeeva, M., Namgaladze, D.
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Bärnthaler, T., Jandl, K., Sill, H., Uhl, B., Schreiber, Y., Grill, M., Thomas, D., Schicho, R., Marsche, G., Frank, S., Heinemann, A., Schuligoi, R.
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Bazarganipour, S., Hausmann, J., Oertel, S., El-Hindi, K., Brachtendorf, S., Blumenstein, I., Kubesch, A., Sprinzl, K., Birod, K., Hahnefeld, L., Trautmann, S., Thomas, D., Herrmann, E., Geisslinger, G., Schiffmann, S., Grösch, S.
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Behrens, F., Köhm, M., Schwaneck, E.C., Schmalzing, M., Gnann, H., Greger, G., Tony, H.-P., Burkhardt, H.
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Behrens, F., Köhm, M., Schwaneck, E.C., Schmalzing, M., Wittig, B.M., Gnann, H., Greger, G., Tony, H.-P., Burkhardt, H.
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Berben, P., Ashworth, L., Beato, S., Bevernage, J., Bruel, J.-L., Butler, J., Dressman, J.B., Schäfer, K., Hutchins, P., Klumpp, L., Mann, J., Nicolai, J., Ojala, K., Patel, S., Powell, S., Rosenblatt, K., Tomaszewska, I., Williams, J., Augustijns, P.
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Bhaskara, R.M., Grumati, P., Garcia-Pardo, J., Kalayil, S., Covarrubias-Pinto, A., Chen, W., Kudryashev, M., Dikic, I., Hummer, G.
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Bhogaraju, S., Bonn, F., Mukherjee, R., Adams, M., Pfleiderer, M.M., Galej, W.P., Matkovic, V., Lopez-Mosqueda, J., Kalayil, S., Shin, D., Dikic, I.
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Bode, E., Heinrich, A.K., Hirschmann, M., Abebew, D., Shi, Y.-N., Vo, T.D., Wesche, F., Shi, Y.-M., Grün, P., Simonyi, S., Keller, N., Engel, Y., Wenski, S., Bennet, R., Beyer, S., Bischoff, I., Buaya, A., Brandt, S., Cakmak, I., Çimen, H., Eckstein, S., Frank, D., Fürst, R., Gand, M., Geisslinger, G., Hazir, S., Henke, M., Heermann, R., Lecaudey, V., Schäfer, W., Schiffmann, S., Schüffler, A., Schwenk, R., Skaljac, M., Thines, E., Thines, M., Ulshöfer, T., Vilcinskas, A., Wichelhaus, T.A., Bode, H.B.
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Borsari, C., Jiménez-Antón, M.D., Eick, J., Bifeld, E., Torrado, J.J., Olías-Molero, A.I., Corral, M.J., Santarem, N., Baptista, C., Severi, L., Gul, S., Wolf, M., Kuzikov, M., Ellinger, B., Reinshagen, J., Witt, G., Linciano, P., Tait, A., Costantino, L., Luciani, R., Tejera Nevado, P., Zander-Dinse, D., Franco, C.H., Ferrari, S., Moraes, C.B., Cordeiro-da-Silva, A., Ponterini, G., Clos, J., Alunda, J.M., Costi, M.P.
Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics (2019) European journal of medicinal chemistry, 183, 111676. http://doi.org/10.1016/j.ejmech.2019.111676

Borsari, C., Santarem, N., Macedo, S., Jiménez-Antón, M.D., Torrado, J.J., Olías-Molero, A.I., Corral, M.J., Tait, A., Ferrari, S., Costantino, L., Luciani, R., Ponterini, G., Gul, S., Kuzikov, M., Ellinger, B., Behrens, B., Reinshagen, J., Alunda, J.M., Cordeiro-da-Silva, A., Costi, M.P.
SAR Studies and Biological Characterization of a Chromen-4-one Derivative as an Anti-Trypanosoma brucei Agent (2019) ACS medicinal chemistry letters, 10 (4), 528–533. http://doi.org/10.1021/acsmedchemlett.8b00565

Braun, J., Schwarting, A., Hammel, L., Legeler, C., Wimmer, P., Färber, L., Behrens, F.
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Brunkhorst-Kanaan, N., Klatt-Schreiner, K., Hackel, J., Schröter, K., Trautmann, S., Hahnefeld, L., Wicker, S., Reif, A., Thomas, D., Geisslinger, G., Kittel-Schneider, S., Tegeder, I.
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Chen, C., Kramer, J.S., Brunst, S., Proschak, E., Scriba, G.K.E.
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Choy, E., Baraliakos, X., Behrens, F., D'Angelo, S., Vlam, K. de, Kirkham, B.W., Østergaard, M., Schett, G.A., Rissler, M., Chaouche-Teyara, K., Perella, C.
The need for comparative data in spondyloarthritis (2019) Arthritis research & therapy, 21 (1), 32. http://doi.org/10.1186/s13075-019-1812-3

Cristofoletti, R., Hens, B., Patel, N., Esteban, V.V., Schmidt, S., Dressman, J.B.
Integrating Drug- and Formulation-Related Properties With Gastrointestinal Tract Variability Using a Product-Specific Particle Size Approach: Case Example Ibuprofen (2019) Journal of pharmaceutical sciences, 108 (12), 3842–3847. http://doi.org/10.1016/j.xphs.2019.09.012

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Dauth, S., Köhm, M., Behrens, F.
Psoriatic arthritis: combinational therapy of biologics and methotrexate - What do we know? (2019) Clinical Trials in Degenerative Diseases, 4 (4), 0. http://doi.org/10.4103/2542-3975.274078

Deutschmann, J., Schneider, A., Gruska, I., Vetter, B., Thomas, D., Kießling, M., Wittmann, S., Herrmann, A., Schindler, M., Milbradt, J., Ferreirós, N., Winkler, T.H., Wiebusch, L., Gramberg, T.
A viral kinase counteracts in vivo restriction of murine cytomegalovirus by SAMHD1 (2019) Nature microbiology, 4 (12), 2273–2284. http://doi.org/10.1038/s41564-019-0529-z

Ditzinger, F., Price, D.J., Nair, A., Becker-Baldus, J., Glaubitz, C., Dressman, J.B., Saal, C., Kuentz, M.
Opportunities for Successful Stabilization of Poor Glass-Forming Drugs: A Stability-Based Comparison of Mesoporous Silica Versus Hot Melt Extrusion Technologies (2019) Pharmaceutics, 11 (11). http://doi.org/10.3390/pharmaceutics11110577

Dreis, C., Ottenlinger, F.M., Putyrski, M., Ernst, A., Huhn, M., Schmidt, K.G., Pfeilschifter, J.M., Radeke, H.H.
Tissue Cytokine IL-33 Modulates the Cytotoxic CD8 T Lymphocyte Activity During Nutrient Deprivation by Regulation of Lineage-Specific Differentiation Programs (2019) Frontiers in immunology, 10, 1698. http://doi.org/10.3389/fimmu.2019.01698

Dufrusine, B., Di Francesco, A., Oddi, S., Scipioni, L., Angelucci, C.B., D'Addario, C., Serafini, M., Häfner, A.-K., Steinhilber, D., Maccarrone, M., Dainese, E.
Iron-Dependent Trafficking of 5-Lipoxygenase and Impact on Human Macrophage Activation (2019) Frontiers in immunology, 10, 1347. http://doi.org/10.3389/fimmu.2019.01347

Ehrnhoefer, D.E., Skotte, N.H., Reinshagen, J., Qiu, X., Windshügel, B., Jaishankar, P., Ladha, S., Petina, O., Khankischpur, M., Nguyen, Y.T.N., Caron, N.S., Razeto, A., Meyer Zu Rheda, M., Deng, Y., Huynh, K.T., Wittig, I., Gribbon, P., Renslo, A.R., Geffken, D., Gul, S., Hayden, M.R.
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Elwakeel, E., Brüggemann, M., Fink, A.F., Schulz, M.H., Schmid, T., Savai, R., Brüne, B., Zarnack, K., Weigert, A.
Phenotypic Plasticity of Fibroblasts during Mammary Carcinoma Development (2019) International journal of molecular sciences, 20 (18). http://doi.org/10.3390/ijms20184438

Elzahhar, P.A., Alaaeddine, R., Ibrahim, T.M., Nassra, R., Ismail, A., Chua, B.S.K., Frkic, R.L., Bruning, J.B., Wallner, N., Knape, T., von Knethen, A., Labib, H., El-Yazbi, A.F., Belal, A.S.F.
Shooting three inflammatory targets with a single bullet: Novel multi-targeting anti-inflammatory glitazones (2019) European journal of medicinal chemistry, 167, 562–582. http://doi.org/10.1016/j.ejmech.2019.02.034

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Members of the endocannabinoid system are distinctly regulated in inflammatory bowel disease and colorectal cancer (2019) Scientific reports, 9 (1), 2358. http://doi.org/10.1038/s41598-019-38865-4

Gul, S.
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Gurke, R., Etyemez, S., Prvulovic, D., Thomas, D., Fleck, S.C., Reif, A., Geisslinger, G., Lötsch, J.
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Gurke, R., Schmidt, D., Thomas, D., Fleck, S.C., Geisslinger, G., Ferreirós, N.
A validated LC-MS/MS method for the determination of homocysteic acid in biological samples (2019) Journal of pharmaceutical and biomedical analysis, 174, 578–587. http://doi.org/10.1016/j.jpba.2019.06.008

Gurke, R., Thomas, D., Schreiber, Y., Schäfer, S.M.G., Fleck, S.C., Geisslinger, G., Ferreirós, N.
Determination of endocannabinoids and endocannabinoid-like substances in human K3EDTA plasma - LC-MS/MS method validation and pre-analytical characteristics (2019) Talanta, 204, 386–394. http://doi.org/10.1016/j.talanta.2019.06.004

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IL-38 Ameliorates Skin Inflammation and Limits IL-17 Production from γδ T Cells (2019) Cell reports, 27 (3), 835-846.e5. http://doi.org/10.1016/j.celrep.2019.03.082

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Computer-Aided Selective Optimization of Side Activities of Talinolol (2019) ACS medicinal chemistry letters, 10 (6), 899–903. http://doi.org/10.1021/acsmedchemlett.9b00075

Hiesinger, K., Wagner, K.M., Hammock, B.D., Proschak, E., Hwang, S.H.
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Advanced in silico modeling explains pharmacokinetics and biodistribution of temoporfin nanocrystals in humans (2019) Journal of controlled release : official journal of the Controlled Release Society, 308, 57–70. http://doi.org/10.1016/j.jconrel.2019.06.029

Janczi, T., Böhm, B.B., Fehrl, Y., DeGiacomo, P., Kinne, R.W., Burkhardt, H.
ADAM15 in Apoptosis Resistance of Synovial Fibroblasts: Converting Fas/CD95 Death Signals Into the Activation of Prosurvival Pathways by Calmodulin Recruitment (2019) Arthritis & rheumatology (Hoboken, N.J.), 71 (1), 63–72. http://doi.org/10.1002/art.40667

Jung, M., Mertens, C., Tomat, E., Brüne, B.
Iron as a Central Player and Promising Target in Cancer Progression (2019) International journal of molecular sciences, 20 (2). http://doi.org/10.3390/ijms20020273

Juretschke, T., Beli, P., Dikic, I.
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Predicting the Changes in Oral Absorption of Weak Base Drugs Under Elevated Gastric pH Using an In Vitro-In Silico-In Vivo Approach: Case Examples-Dipyridamole, Prasugrel, and Nelfinavir (2019) Journal of pharmaceutical sciences, 108 (1), 584–591. http://doi.org/10.1016/j.xphs.2018.11.008

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PBPK modeling coupled with biorelevant dissolution to forecast the oral performance of amorphous solid dispersion formulations (2019) European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 135, 83–90. http://doi.org/10.1016/j.ejps.2019.05.013

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Gliotoxin from Aspergillus fumigatus Abrogates Leukotriene B4 Formation through Inhibition of Leukotriene A4 Hydrolase (2019) Cell chemical biology, 26 (4), 524-534.e5. http://doi.org/10.1016/j.chembiol.2019.01.001

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Ceramides as Novel Disease Biomarkers (2019) Trends in molecular medicine, 25 (1), 20–32. http://doi.org/10.1016/j.molmed.2018.10.009

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Structural Insights into the Development of Cycloguanil Derivatives as Trypanosoma brucei Pteridine-Reductase-1 Inhibitors (2019) ACS infectious diseases, 5 (7), 1105–1114. http://doi.org/10.1021/acsinfecdis.8b00358

Lim, R., Sugino, T., Nolte, H., Andrade, J., Zimmermann, B., Shi, C., Doddaballapur, A., Ong, Y.T., Wilhelm, K., Fasse, J.W.D., Ernst, A., Kaulich, M., Husnjak, K., Boettger, T., Guenther, S., Braun, T., Krüger, M., Benedito, R., Dikic, I., Potente, M.
Deubiquitinase USP10 regulates Notch signaling in the endothelium (2019) Science (New York, N.Y.), 364 (6436), 188–193. http://doi.org/10.1126/science.aat0778

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Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections (2019) Journal of medicinal chemistry, 62 (8), 3989–4012. http://doi.org/10.1021/acs.jmedchem.8b02021

Linke, B., Meyer Dos Santos, S., Picard-Willems, B., Keese, M., Harder, S., Geisslinger, G., Scholich, K.
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Litou, C., Patel, N., Turner, D.B., Kostewicz, E., Kuentz, M., Box, K.J., Dressman, J.B.
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A data science-based analysis of seasonal patterns in outpatient presentations due to olfactory dysfunction (2019) Rhinology. http://doi.org/10.4193/Rhin19.099

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Clinical Usefulness of Self-Rated Olfactory Performance-A Data Science-Based Assessment of 6000 Patients (2019) Chemical senses, 44 (6), 357–364. http://doi.org/10.1093/chemse/bjz029

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Machine-learned analysis of side-differences in odor identification performance (2019) Neuroscience, 422, 44–53. http://doi.org/10.1016/j.neuroscience.2019.09.033

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Lötsch, J., Walter, C., Zunftmeister, M., Zinn, S., Wolters, M., Ferreirós, N., Rossmanith, T., Oertel, B.G., Geisslinger, G.
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Martin, L.M., Möller, M., Weiss, U., Russe, O.Q., Scholich, K., Pierre, S., Geisslinger, G., Niederberger, E.
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NIPSNAP Beacons in Mitophagy (2019) Developmental cell, 49 (4), 503–505. http://doi.org/10.1016/j.devcel.2019.05.008

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Simultaneous response in several domains in patients with psoriatic disease treated with etanercept as monotherapy or in combination with conventional synthetic disease-modifying antirheumatic drugs (2018) Journal of Rheumatology, 45 (6), 802-810. http://doi.org/10.3899/jrheum.170932

Blum, L., Schiffmann, S., Parnham, M.J.
Immunomodulation by antibiotics (2018) Fighting Antimicrobial Resistance (IAPC Book). http://doi.org/10.5599/obp.15.11

Blum, L., Tafferner, N., Spring, I., Kurz, J., deBruin, N., Geißlinger, G., Parnham, M.J., Schiffmann, S.
Dietary phytol reduces clinical symptoms in experimental autoimmune encephalomyelitis (EAE) at least partially by modulating NOX2 expression (2018) Journal of Molecular Medicine, 96 (10), 1131-1144. http://doi.org/10.1007/s00109-018-1689-7

Böhm, B.B., Fehrl, Y., Janczi, T., Schneider, N., Burkhardt, H.
Cell adhesion-induced transient interaction of ADAM15 with poly(A) binding protein at the cell membrane colocalizes with mRNA translation (2018) PLoS ONE, 13 (9), e203847. http://doi.org/10.1371/journal.pone.0203847

Bosma, R., Witt, G., Vaas, L.A.I., Josimovic, I., Gribbon, P., Vischer, H.F., Gul, S., Leurs, R.
The Target Residence Time of Antihistamines Determines Their Antagonism of the G Protein-Coupled Histamine H1 Receptor (2017) Front Pharmacol, 8:667. http://doi.org/10.3389/fphar.2017.00667

Brachtendorf, S., Wanger, R.A., Birod, K., Thomas, D., Trautmann, S., Wegner, M.-S., Fuhrmann, D.C., Brüne, B., Geißlinger, G., Grösch, S.
Chemosensitivity of human colon cancer cells is influenced by a p53-dependent enhancement of ceramide synthase 5 and induction of autophagy (2018) Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1863 (10), 1214-1227. http://doi.org/10.1016/j.bbalip.2018.07.011

Brand, S., Roy, S., Schröder, P., Rathmer, B., Roos, J., Kapoor, S., Patil, S., Pommerenke, C., Maier, T., Janning, P., Eberth, S., Steinhilber, D., Schade, D., Schneider, G., Kumar, K., Ziegler, S., Waldmann, H.
Combined proteomic and in silico target identification reveal a role for 5-Lipoxygenase in developmental signaling pathways (2018) Cell Chemical Biology, 25 (9), 1095-1106.e23. http://doi.org/10.1016/j.chembiol.2018.05.016

Brandt, S.C., Ellinger, B., van Nguyen, T., Thi, Q.D., van Nguyen, G., Baschien, C., Yurkov, A., Hahnke, R.L., Schäfer, W., Gand, M.
A unique fungal strain collection from Vietnam characterized for high performance degraders of bioecological important biopolymers and lipids (2018) PLoS ONE, 13(8). http://doi.org/10.1371/journal.pone.0202695

Büttner, D., Kramer, J.S., Klingler, F.-M., Wittmann, S.K., Hartmann, M.R., Kurz, C.G., Kohnhäuser, D., Weizel, L., Brüggerhoff, A., Frank, D., Steinhilber, D., Wichelhaus, T.A., Pogoryelov, D., Proschak, E.
Challenges in the Development of a Thiol-Based Broad-Spectrum Inhibitor for Metallo-β-Lactamases (2018) ACS Infectious Diseases, 4 (3), 360-372. http://doi.org/10.1021/acsinfecdis.7b00129

Burk, O., Kuzikov, M., Kronenberger, T., Jeske, J., Keminer, O., Thasler, W.E., Schwab, M., Wrenger, C., Windshügel, B.
Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles (2018) Archives of Toxicology, 92 (4), 1435-1451. http://doi.org/10.1007/s00204-018-2165-4

D – F

Dauth, S., Köhm, M., Rossmanith, T., Herrmann, E., Lehn, A., Burkhardt, H., Behrens, F.
Stellenwert der Kombination von Biologika mit Methotrexat in der Behandlung der Psoriasisarthritis - Fragen bleiben offen (2018) Zeitschrift fur Rheumatologie.  http://doi.org/10.1007/s00393-018-0533-3

de Bruin, N., Ferreirós, N., Schmidt, M., Hofmann, M., Angioni, C., Geisslinger, G., Parnham, M.J. Mutual inversion of flurbiprofen enantiomers in various rat and mouse strains (2018) Chirality, 30 (5), 632-641. http://doi.org/10.1002/chir.22826

de Witte, W.E.A., Versfelt, J.W., Kuzikov, M., Rolland, S., Georgi, V., Gribbon, P., Gul, S., Huntjens, D., van der Graaf, P.H., Danhof, M., Fernández-Montalván, A., Witt, G., de Lange, E.C.M.
In vitro and in silico analysis of the effects of D2 receptor antagonist target binding kinetics on the cellular response to fluctuating dopamine concentrations (2018) Br J Pharmacol, 175 (21), 4121-4136. http://doi.org/10.1111/bph.14456

Eresch, J., Stumpf, M., Koch, A., Vutukuri, R., Ferreirós, N., Schreiber, Y., Schröder, K., Devraj, K., Popp, R., Hattenbach, L.-O., Pfeilschifter, J., Pfeilschifter, W.Sphingosine kinase 2 modulates retinal neovascularization in the mouse model of oxygen-induced retinopathy(2018) Investigative Ophthalmology and Visual Science, 59 (2), 653-661. http://doi.org/10.1167/iovs.17-22544

Fiehn, C., Holle, J., Iking-Konert, C., Leipe, J., Weseloh, C., Frerix, M., Alten, R., Behrens, F., Baerwald, C., Braun, J., Burkhardt, H., Burmester, G., Detert, J., Gaubitz, M., Gause, A., Gromnica-Ihle, E., Kellner, H., Krause, A., Kuipers, J., Lorenz, H.-M., Müller-Ladner, U., Nothacker, M., Nüsslein, H., Rubbert-Roth, A., Schneider, M., Schulze-Koops, H., Seitz, S., Sitter, H., Specker, C., Tony, H.-P., Wassenberg, S., Wollenhaupt, J., Krüger, K.
S2e guideline: treatment of rheumatoid arthritis with disease-modifying drugs (2018) Zeitschrift fur Rheumatologie, 77, 35-53. http://doi.org/10.1007/s00393-018-0481-y

Genovese, M.C., Combe, B., Kremer, J.M., Tsai, T.-F., Behrens, F., Adams, D.H., Lee, C., Kerr, L., Nash, P.
Safety and efficacy of ixekizumab in patients with PsA and previous inadequate response to TNF inhibitors: week 52 results from SPIRIT-P2 (2018) Rheumatology (Oxford, England), 57 (11), 2001-2011. http://doi.org/10.1093/rheumatology/key182

Gossec, L., McGonagle, D., Korotaeva, T., Lubrano, E., De Miguel, E., Østergaard, M., Behrens, F. Minimal disease activity as a treatment target in psoriatic arthritis: A review of the literature (2018) Journal of Rheumatology, 45 (1), 6-13. http://doi.org/10.3899/jrheum.170449

Häupl, T., Skapenko, A., Hoppe, B., Skriner, K., Burkhardt, H., Poddubnyy, D., Ohrndorf, S., Sewerin, P., Mansmann, U., Stuhlmüller, B., Schulze-Koops, H., Burmester, G.R.
Biomarkers and imaging for diagnosis and stratification of rheumatoid arthritis and spondylarthritis in the BMBF consortium ArthroMark (2018) Zeitschrift fur Rheumatologie, 77, 16-23. http://doi.org/10.1007/s00393-018-0458-x

Hausen, J., Otte, J.C., Legradi, J., Yang, L., Strähle, U., Fenske, M., Hecker, M., Tang, S., Hammers-Wirtz, M., Hollert, H., Keiter, S.H., Ottermanns, R.
Fishing for contaminants: identification of three mechanism specific transcriptome signatures using Danio rerio embryos (2018) Environmental Science and Pollution Research, 25 (5), 4023-4036. http://doi.org/10.1007/s11356-017-8977-6

Heitel, P., Gellrich, L., Heering, J., Goebel, T., Kahnt, A., Proschak, E., Schubert-Zsilavecz, M., Merk, D.
Urate transporter inhibitor lesinurad is a selective peroxisome proliferator-activated receptor gamma modulator (sPPARγM) in vitro (2018) Scientific Reports, 8 (1), 13554. http://doi.org/10.1038/s41598-018-31833-4

Hering, Y., Berthier, A., Duez, H., Lefebvre, P., Deprez, B., Gribbon, P., Wolf, M., Reinshagen, J., Halley, F., Hannemann, J., Böger, R., Staels, B., Gul, S.
Development and implementation of a cell-based assay to discover agonists of the nuclear receptor REV-ERBα (2018) Journal of Biological Methods, 5 (3), e94. http://doi.org/10.1038/s41598-018-31833-4

Hitzel, J., Lee, E., Zhang, Y., Bibli, S.I., Li, X., Zukunft, S., Pflüger, B., Hu, J., Schürmann, C., Vasconez, A.E., Oo, J.A., Kratzer, A., Kumar, S., Rezende, F., Josipovic, I., Thomas, D., Giral, H., Schreiber, Y., Geisslinger, G., Fork, C., Yang, X., Sigala, F., Romanoski, C.E., Kroll, J., Jo, H., Landmesser, U., Lusis, A.J., Namgaladze, D., Fleming, I., Leisegang, M.S., Zhu, J., Brandes, R.P. Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells (2018) Nature Communications, 9 (1), art. no. 2292. http://doi.org/10.1038/s41467-018-04602-0

Hofmann, M.C.J., Schmidt, M., Arne, O., Geisslinger, G., Parnham, M.J., de Bruin, N.M.W.J.
Non-invasive bioluminescence imaging as a standardized assessment measure in mouse models of dermal inflammation (2018) Journal of Dermatological Science, 91 (2), 153-163. http://doi.org/10.1016/j.jdermsci.2018.04.013

Jung, F., Nothnagel, L., Gao, F., Thurn, M., Vogel, V., Wacker, M.G. A comparison of two biorelevant in vitro drug release methods for nanotherapeutics based on advanced physiologically-based pharmacokinetic modelling (2018) European Journal of Pharmaceutics and Biopharmaceutics, 127, 462-470. http://doi.org/10.1016/j.ejpb.2018.03.010

Kern, K., Schäfer, S.M.G., Cohnen, J., Pierre, S., Osthues, T., Tarighi, N., Hohmann, S., Ferreiros, N., Brüne, B., Weigert, A., Geißlinger, G., Sisignano, M., Scholich, K.
The G2A receptor controls polarization of macrophage by determining their localization within the inflamed tissue (2018) Frontiers in Immunology, 9, 2261. http://doi.org/10.3389/fimmu.2018.02261

Kirchner, J., Brüne, B., Namgaladze, D. AICAR inhibits NFκB DNA binding independently of AMPK to attenuate LPS-triggered inflammatory responses in human macrophages (2018) Scientific Reports, 8 (1), art. no. 7801, http://doi.org/10.1038/s41598-018-26102-3

Knecht, K.M., Buzovetsky, O., Schneider, C., Thomas, D., Srikanth, V., Kaderali, L., Tofoleanu, F., Reiss, K., Ferreirós, N., Geißlinger, G., Batista, V.S., Ji, X., Cinatl, J. Jr., Keppler, O.T., Xiong, Y.
The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1 (2018) Proceedings of the National Academy of Sciences of the United States of America, 115 (43), E10022-E10031. http://doi.org/10.1073/pnas.1805593115

Kraft, C., Boya, P., Codogno, P., Elazar, Z., Eskelinen, E.-L., Farrés, J., Kirkin, V., Jungbluth, H., Martinez, A., Pless, O., Primard, C., Proikas-Cezanne, T., Simonsen, A., Reggiori, F.
Driving next-generation autophagy researchers towards translation (DRIVE), an international PhD training program on autophagy (2018) Autophagy. 13,1-5. Online first. http://doi.org/10.1080/15548627.2018.1515532Kramer, J., Désor, V., Brunst, S., Wittmann, S.K., Lausen, J., Heering, J., Proschak, A., Proschak, E. A coupled fluorescence-based assay for the detection of protein arginine N-methyltransferase 6 (PRMT6) enzymatic activity (2018) Analytical Biochemistry, 547, 7-13. http://doi.org/10.1016/j.ab.2018.01.023

Kramer, J., Désor, V., Brunst, S., Wittmann, S.K., Lausen, J., Heering, J., Proschak, A., Proschak, E.
A coupled fluorescence-based assay for the detection of protein arginine N-methyltransferase 6 (PRMT6) enzymatic activity (2018) Analytical Biochemistry, 547, 7-13. http://doi.org/10.1016/j.ab.2018.01.023

Kringel, D., Geißlinger, G., Resch, E., Oertel, B.G., Thrun,M.C., Heinemann, S., Lötsch, J.
Machine-learned analysis of the association of next-generation sequencing-based human TRPV1 and TRPA1 genotypes with the sensitivity to heat stimuli and topically applied capsaicin (2018) Pain, 159 (7), 1366-1381. http://doi.org/10.1097/j.pain.0000000000001222

Kringel, D., Kaunisto, M.A., Lippmann, C., Kalso, E., Lötsch, J.
Development of an AmpliSeqTMPanel for next-generation sequencing of a set of genetic predictors of persisting pain (2018) Frontiers in Pharmacology, 9, 1008. http://doi.org/10.3389/fphar.2018.01008

Kringel, D., Lippmann, C., Parnham, M.J., Kalso, E., Ultsch, A., Lötsch, J.
A machine-learned analysis of human gene polymorphisms modulating persisting pain points to major roles of neuroimmune processes (2018) European Journal of Pain, 22 (10), 1735-1756. http://doi.org/10.1002/ejp.1270

Kronenberger, T., Windshügel, B., Wrenger, C., Honorio, K.M., Maltarollo, V.G. On the relationship of anthranilic derivatives structure and the FXR (Farnesoid X receptor) agonist activity (2018) Journal of Biomolecular Structure and Dynamics, 1-14. Article in Press. http://doi.org/10.1080/07391102.2017.1417161

Kühn, B., Brat, C., Fettel, J., Hellmuth, N., Maucher, I.V., Bulut, U., Hock, K.J., Grimmer, J., Manolikakes, G., Rühl, M., Kühn, A., Zacharowski, K., Matrone, C., Urbschat, A., Roos, J., Steinhilber, D., Maier, T.J.
Anti-inflammatory nitro-fatty acids suppress tumor growth by triggering mitochondrial dysfunction and activation of the intrinsic apoptotic pathway in colorectal cancer cells (2018) Biochemical Pharmacology, 155, 48-60. http://doi.org/10.1016/j.bcp.2018.06.014

Kurz, J., Brunkhorst, R., Foerch, C., Blum, L., Henke, M., Gabriel, L., Ulshöfer, T., Ferreirós, N., Parnham, M.J., Geißlinger, G., Schiffmann, S.
The relevance of ceramides and their synthesizing enzymes for multiple sclerosis (2018) Clinical Science, 132 (17), 1963-1976. http://doi.org/10.1042/CS20180506

Linciano, P., Moraes, C.B., Alcantara, L.M., Franco, C.H., Pascoalino, B., Freitas-Junior, L.H., Macedo, S., Santarem, N., Cordeiro-da-Silva, A., Gul, S., Witt, G., Kuzikov, M., Ellinger, B., Ferrari, S., Luciani, R., Quotadamo, A., Costantino, L., Costi, M.P.
Aryl thiosemicarbazones for the treatment of trypanosomatidic infections (2018) European Journal of Medicinal Chemistry, 25;146, 423-434. http://doi.org/10.1016/j.ejmech.2018.01.043

Lippmann, C., Kringel, D., Ultsch, A., Lötsch, J. Computational functional genomics-based approaches in analgesic drug discovery and repurposing (2018) Pharmacogenomics, 19 (9), 783-797. http://doi.org/10.2217/pgs-2018-0036

Lötsch, J., Geisslinger, G., Heinemann, S., Lerch, F., Oertel, B.G., Ultsch, A.
Quantitative sensory testing response patterns to capsaicin- and ultraviolet-B-induced local skin hypersensitization in healthy subjects: A machine-learned analysis (2018) Pain, 159 (1), 11-24. http://doi.org/10.1097/j.pain.0000000000001008

Lötsch, J., Kringel, D.
Use of Computational Functional Genomics in Drug Discovery and Repurposing for Analgesic Indications (2018) Clinical Pharmacology and Therapeutics, . Article in Press. http://doi.org/10.1002/cpt.960

Lötsch, J., Lerch, F., Djaldetti, R., Tegder, I., Ultsch, A.
dentification of disease-distinct complex biomarker patterns by means of unsupervised machine-learning using an interactive R toolbox (Umatrix) (2018) BMC Big Data Analytics, 3. http://doi.org/10.1186/s41044-018-0032-1

Lötsch, J., Schiffmann, S., Schmitz, K., Brunkhorst, R., Lerch, F., Ferreiros, N., Wicker, S., Tegeder, I., Geißlinger, G., Ultsch, A.
Machine-learning based lipid mediator serum concentration patterns allow identification of multiple sclerosis patients with high accuracy (2018) Scientific Reports, 8 (1), 14884. http://doi.org/10.1038/s41598-018-33077-8

Lötsch, J., Sipilä, R., Dimova, V., Kalso, E.
Machine-learned selection of psychological questionnaire items relevant to the development of persistent pain after breast cancer surgery (2018) British Journal of Anaesthesia, 121 (5), 1123-1132. http://doi.org/10.1016/j.bja.2018.06.007

Lötsch, J., Sipilä, R., Tasmuth, T., Kringel, D., Estlander, A.-M., Meretoja, T., Kalso, E., Ultsch, A. Machine-learning-derived classifier predicts absence of persistent pain after breast cancer surgery with high accuracy (2018) Breast Cancer Research and Treatment, 1-13. Article in Press. http://doi.org/10.1007/s10549-018-4841-8

Lötsch, J., Ultsch, A.
Machine learning in pain research (2018) Pain, 159 (4), 623-630. http://doi.org/10.1097/j.pain.0000000000001118

Lötsch, J., Weyer-Menkhoff, I., Tegeder, I. Current evidence of cannabinoid-based analgesia obtained in preclinical and human experimental settings (2018) European Journal of Pain (United Kingdom), 22 (3), 471-484. http://doi.org/10.1002/ejp.1148

Lukin, A., Kramer, J., Hartmann, M., Weizel, L., Hernandez-Olmos, V., Falahati, K., Burghardt, I., Kalinchenkova, N., Bagnyukova, D., Zhurilo, N., Rautio, J., Forsberg, M., Ihalainen, J., Auriola, S., Leppänen, J., Konstantinov, I., Pogoryelov, D., Proschak, E., Dar‘in, D., Krasavin, M.
Discovery of polar spirocyclic orally bioavailable urea inhibitors of soluble epoxide hydrolase (2018) Bioorganic Chemistry, 80, 655-667. http://doi.org/10.1016/j.bioorg.2018.07.014

M – O

Maltarollo, V.G., Kronenberger, T., Windshugel, B., Wrenger, C., Trossini, G.H.G., Honorio, K.M.
Advances and Challenges in Drug Design of PPARδ Ligands (2018) Curr Drug Targets. 19 (2),144-154. http://doi.org/10.2174/1389450118666170414113159

Mertens, C., Mora, J., Ören, B., Grein, S., Winslow, S., Scholich, K., Weigert, A., Malmström, P., Forsare, C., Fernö, M., Schmid, T., Brüne, B., Jung, M.
Macrophage-derived lipocalin-2 transports iron in the tumor microenvironment (2018) OncoImmunology, 7 (3), e1408751. http://doi.org/10.1080/2162402X.2017.1408751

Moreno-Cinos, C., Sassetti, E., Salado, IG., Witt, G., Benramdane, S., Reinhardt, L., Durante Cruz, C., Joossens, J., Van der Veken, P., Brotz-Oesterhelt, H., Tammela, P., Winterhalter, M., Gribbon, P., Windshügel, B., Augustyns, K.
α-Amino diphenyl phosphonates as novel inhibitors of ­Escherichia coli ClpP protease (2018) Journal of Medicinal Chemistry, American Chemical Society. Online first. http://doi.org/10.1021/acs.jmedchem.8b01466.

Nash, P., Behrens, F., Orbai, A.-M., Rathmann, S.S., Adams, D.H., Benichou, O., Deodhar, A.
Ixekizumab is efficacious when used alone or when added to conventional synthetic disease-modifying antirheumatic drugs (cDMARDs) in patients with active psoriatic arthritis and previous inadequate response or intolerance to tumour necrosis factor inhibitors (2018) RMD Open, 4 (2), e000692. http://doi.org/10.1136/rmdopen-2018-000692

Nothnagel, L., Wacker, M.G. How to measure release from nanosized carriers? (2018) European Journal of Pharmaceutical Sciences, 120, 199-211. http://doi.org/10.1016/j.ejps.2018.05.004

P – R

Patas, K., Willing, A., Demiralay, C., Engler, J.B., Lupu, A., Ramien, C., Schäfer, T., Gach, C., Stumm, L., Chan, K., Vignali, M., Arck, P.C., Friese, M.A., Pless, O., Wiedemann, K., Agorastos, A., Gold, S.M. T cell phenotype and T cell receptor repertoire in patients with major depressive disorder (2018) Frontiers in Immunology, 9 (FEB), art. no. 291, http://doi.org/10.3389/fimmu.2018.00291

Piña, M., Colas, P., Cancio, I., Audic, A., Bosser, L., Canario, A., Gribbon, P., Johnston, IA., Kervella, AE., Kooistra, WHCF., Merciecca, M., Magoulas, A., Nardello, I., Smith, D., Pade, N., Robinson, D., Schoen, A., Schultz, F., Kloareg, B.
The European Marine Biological Research Infrastructure Cluster: An Alliance of European Research Infrastructures to Promote the Blue Bioeconomy (2018) Grand Challenges in Marine Biotechnology, Springer, 405-421. http://doi.org/10.1007/978-3-319-69075-9_10

Pleli, T., Mondorf, A., Ferreiros, N., Thomas, D., Dvorak, K., Biondi, R.M., Heringdorf, D.M.Z., Zeuzem, S., Geißlinger, G., Zimmermann, H., Waidmann, O., Piiper, A.
Activation of adenylyl cyclase causes stimulation of adenosine receptors (2018) Cellular Physiology and Biochemistry, 45 (6), 2516-2528. http://doi.org/10.1159/000488270

Proft, F., Schulze-Koops, H., Grunke, M., Schrezenmeier, E., Halleck, F., Henes, J., Unger, L., Schmidt, E., Fiehn, C., Jacobi, A., Iking-Konert, C., Kneitz, C., Schmidt, R.E., Bannert, B., Voll, R.E., Fischer-Betz, R., Kötter, I., Tony, H.P., Holle, J., Aringer, M., Erler, A., Behrens, F., Burmester, G.R., Dörner, T.
Safety and efficacy of off-label use of biologic therapies in patients with inflammatory rheumatic diseases refractory to standard of care therapy: Data from a nationwide German registry (GRAID2) [Sicherheit und Wirksamkeitshinweise zum Off-label-Einsatz von Biologikatherapien nach Versagen konventioneller Therapien bei Patienten mit entzündlich rheumatischen Erkrankungen: Ergebnisse eines nationalen Registers (GRAID2)] (2018) Zeitschrift fur Rheumatologie, 77 (1), 28-39. http://doi.org/10.1007/s00393-017-0330-4

Ringleb, J., Strack, E., Angioni, C., Geißlinger, G., Steinhilber, D., Weigert, A., Brüne, B.
Apoptotic Cancer Cells Suppress 5-Lipoxygenase in Tumor-Associated Macrophages (2018) Journal of Immunology, 200 (2), 857-868. http://doi.org/10.4049/jimmunol.1700609

Roos, J., Peters, M., Maucher, I.V., Kühn, B., Fettel, J., Hellmuth, N., Brat, C., Sommer, B., Urbschat, A., Piesche, M., Vogel, A., Proschak, E., Blöcher, R., Buscató, E., Häfner, A.-K., Matrone, C., Werz, O., Heidler, J., Wittig, I., Angioni, C., Geisslinger, G., Parnham, M.J., Zacharowski, K., Steinhilber, D., Maier, T.J. Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase: A Possible Key to Future Antileukotriene Therapy (2018) Antioxidants and Redox Signaling, 28 (14), 1265-1285. http://doi.org/10.1089/ars.2017.7155

S – U

Sala, A., Proschak, E., Steinhilber, D., Rovati, G.E.
Two-pronged approach to anti-inflammatory therapy through the modulation of the arachidonic acid cascade (2018) Biochemical Pharmacology, 158, 161-173. http://doi.org/10.1016/j.bcp.2018.10.007

Schierle, S., Flauaus, C., Heitel, P., Willems, S., Schmidt, J., Kaiser, A., Weizel, L., Goebel, T., Kahnt, A.S., Geißlinger, G., Steinhilber, D., Wurglics, M., Rovati, G.E., Schmidtko, A., Proschak, E., Merk, D.
Boosting anti-inflammatory potency of zafirlukast by designed polypharmacology (2018) Journal of Medicinal Chemistry, 61 (13), 5758-5764. http://doi.org/10.1021/acs.jmedchem.8b00458

Sehnert, B., Burkhardt, H., Finzel, S., Dübel, S., Voll, R.E. The sneaking ligand approach for cell type-specific modulation of intracellular signalling pathways (2018) Clinical Immunology, 186,  14-20. http://doi.org/10.1016/j.clim.2017.08.018

Sekar, D., Govene, L., Del Río, M.-L., Sirait-Fischer, E., Fink, A.F., Brüne, B., Rodriguez-Barbosa, J.I., Weigert, A. Downregulation of BTLA on NKT cells promotes tumor immune control in a mouse model of mammary Carcinoma (2018) International Journal of Molecular Sciences, 19 (3), art. no. 752, http://doi.org/10.3390/ijms19030752

Shiratori, H., Feinweber, C., Luckhardt, S., Wallner, N., Geisslinger, G., Weigert, A., Parnham, M.J. An in vitro test system for compounds that modulate human inflammatory macrophage polarization (2018) European Journal of Pharmacology, 833, 328-338. http://doi.org/10.1016/j.ejphar.2018.06.017

Snodgrass, R.G., Zezina, E., Namgaladze, D., Gupta, S., Angioni, C., Geißlinger, G., Lütjohann, D., Brüne, B.
A novel function for 15-Lipoxygenases in cholesterol homeostasis and CCL17 production in human macrophages. (2018) Front Immunol 1906 (9), 1-16. http://doi.org/10.3389/fimu.2018.01906

Sonnack, L., Klawonn, T., Kriehuber, R., Hollert, H., Schäfers, C., Fenske, M.
Comparative analysis of the transcriptome responses of zebrafish embryos after exposure to low concentrations of cadmium, cobalt and copper (2018) Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics, 25, 99-108. http://doi.org/10.1016/j.cbd.2017.12.001

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